Reduced STAG2 expression in myelodysplastic neoplasms and acute myeloid leukemia myelodysplasia-related: a potential biomarker associated with aneuploidy and disease progression

BackgroundMyelodysplastic neoplasms (MDS) are a clonal hematopoietic stem cell disease with an increased risk of progression to acute myeloid leukemia (AML). Cytogenetic abnormalities, mainly aneuploidies, occur in 40%–60% of cases and are critical for MDS diagnosis and prognosis. Nevertheless, the...

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Bibliografski detalji

Glavni autori:	Beatriz Ferreira da Silva, Nina Carrossini Bastos, Tatiana Fonseca Alvarenga, Rafael Mina Piergiorge, Verônica Goulart Moreira, Ana Paula Bueno, Cristiane Bedran Milito, Cíntia Barros Santos-Rebouças, Teresa De Souza Fernandez
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-03-01
Serija:	Frontiers in Cell and Developmental Biology
Teme:	AML-MR aneuploidy biomarker leukemic evolution myelodysplastic neoplasms STAG2
Online pristup:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1731983/full
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