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Emergence of Ceftazidime/Avibactam and Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Due to In-Host Microevolution

Klebsiella pneumoniae can cause both hospital- and community-acquired clinical infections. Last-line antibiotics against carbapenem-resistant K. pneumoniae (CRKP), such as ceftazidime/avibactam (CZA) and tigecycline (TGC), remain limited as treatment choices. This study aimed to investigate the mech...

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Principais autores: Xinhong Han, Qiucheng Shi, Yihan Mao, Jingjing Quan, Ping Zhang, Peng Lan, Yan Jiang, Dongdong Zhao, Xueqing Wu, Xiaoting Hua, Yunsong Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-10-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
carbapenem-resistant K. pneumoniae
ceftazidime/avibactam
tigecycline
in vivo
insertion sequences
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2021.757470/full
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