Catalytic enantioselective Gilman-Speeter synthesis of β-lactams by nucleophilic activation of carboxylic acids
A novel Gilman-Speeter synthesis of β-lactams has been developed that was rendered highly enantioselective by virtue of isothiourea catalyst’s nucleophilicity. This process depends upon the HATU conversion of carboxylic acids to activated esters which then undergo attack by the homochiral catalyst a...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2023-12-01
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| Serier: | Results in Chemistry |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2211715623003065 |
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