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Catalytic enantioselective Gilman-Speeter synthesis of β-lactams by nucleophilic activation of carboxylic acids

A novel Gilman-Speeter synthesis of β-lactams has been developed that was rendered highly enantioselective by virtue of isothiourea catalyst’s nucleophilicity. This process depends upon the HATU conversion of carboxylic acids to activated esters which then undergo attack by the homochiral catalyst a...

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Bibliografiske detaljer
Principais autores: Vasileios Demos, Adreana Karakoula, Minas Paraskeva, Konstantina Moraiti, Konstantina Petrou, Paraskevi Kermanou, Plato A. Magriotis
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-12-01
Serier:Results in Chemistry
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Online adgang:http://www.sciencedirect.com/science/article/pii/S2211715623003065
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