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Knockdown of YAP inhibits growth in Hep-2 laryngeal cancer cells via epithelial-mesenchymal transition and the Wnt/β-catenin pathway

Abstract Background Yes-associated protein (YAP) plays a crucial role in tumour development and it is the main effector of the Hippo signalling pathway. However, the mechanism underlying YAP downregulation in laryngeal cancer is still unclear. In our previous study, we found that YAP, compared with...

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Principais autores: Xiaomin Tang, Yuxuan Sun, Ganglun Wan, Jiaqiang Sun, Jingwu Sun, Chunchen Pan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-07-01
Serier:BMC Cancer
Fag:
YAP
laryngeal cancer
Wnt/β-catenin
Hep-2
EMT
Online adgang:http://link.springer.com/article/10.1186/s12885-019-5832-9
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