Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum.

There is need for a more efficient cell-based assay amenable to high-throughput drug screening against Giardia lamblia. Here, we report the development of a screening method utilizing G. lamblia engineered to express red-shifted firefly luciferase. Parasite growth and replication were quantified usi...

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Hlavní autoři:	Kelly M Hennessey, Ilse C Rogiers, Han-Wei Shih, Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Grant R Whitman, Lynn K Barrett, Ethan A Merritt, Alexander R Paredez, Kayode K Ojo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2018-08-01
Edice:	PLoS Neglected Tropical Diseases
On-line přístup:	http://europepmc.org/articles/PMC6095626?pdf=render
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