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The PI3K-Akt-CCND2 axis couples metabolic reprogramming with macrophage M1 polarization

Abstract Dysregulated macrophage M1 polarization is a core pathological feature of inflammatory disorders. However, the crosstalk between metabolic reprogramming and cell-cycle regulator Ccnd2 during macrophage polarization remains largely unclear. This study explored the role of the PI3K-Akt-Ccnd2...

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Principais autores: Xiaoyu Liu, Wei Shi, Lin Chai, Jianyuan Liu, Yanqian Su, Shuxing Wei, Chunkai Jia, Xiaomei Zhu, Shubin Guo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-05-01
Serier:Scientific Reports
Fag:
Sepsis
Macrophage polarization
Ccnd2
Metabolic reprogramming
PI3K-Akt signaling
LPS
Online adgang:https://doi.org/10.1038/s41598-026-51817-z
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