Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

RIPK1 integrates signals that drive both NF-κB activation and cell death pathways. Here Zhang et al. generate RIPK1 knock-in mice lacking a major ubiquitination site and demonstrate that this modification is important to suppress cell death during embryogenesis and inflammation postnatally.

Detalhes bibliográficos

Principais autores:	Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang, Haibing Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2019-09-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-019-11839-w
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