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Saquayamycin B<sub>1</sub> Suppresses Proliferation, Invasion, and Migration by Inhibiting PI3K/AKT Signaling Pathway in Human Colorectal Cancer Cells

Moromycin B (Mor B), saquayamycin B<sub>1</sub> (Saq B<sub>1</sub>), saquayamycin B (Saq B), and landomycin N (Lan N), four angucyclines produced by the marine-derived actinomycete <i>Streptomyces</i> sp., are a class of polyketone compounds containing benzanthracene. Here, the structure–activity re...

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Autori principali: Jianjiang Li, Ningning Han, Hao Zhang, Xiaoyu Xie, Yaoyao Zhu, E Zhang, Jiahui Ma, Chuangeng Shang, Mengxiong Yin, Weidong Xie, Xia Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-09-01
Serie:Marine Drugs
Soggetti:
saquayamycin B<sub>1</sub>
colorectal cancer
PI3K/AKT
EMT
apoptosis
structure–activity relationship
Accesso online:https://www.mdpi.com/1660-3397/20/9/570
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