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FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer

Abstract Background Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the main cause of death in BC. However, to date molecular mechanisms underlyi...

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Principais autores: Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen, Xin Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-10-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
Breast cancer
Circulating tumor cells
FOXD1
RalA-ANXA2-Src complex
ERK1/2 inhibitor
Online adgang:https://doi.org/10.1186/s13046-022-02504-0
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