Is Meropenem as a Monotherapy Truly Incompetent for Meropenem-Nonsusceptible Bacterial Strains? A Pharmacokinetic/Pharmacodynamic Modeling With Monte Carlo Simulation

Infections due to meropenem-nonsusceptible bacterial strains (MNBSs) with meropenem minimum inhibitory concentrations (MICs) ≥ 16 mg/L have become an urgent problem. Currently, the optimal treatment strategy for these cases remains uncertain due to some limitations of currently available mono- and c...

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Автори:	Xiangqing Song, Yi Wu, Lizhi Cao, Dunwu Yao, Minghui Long
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2019-11-01
Серія:	Frontiers in Microbiology
Предмети:	meropenem monotherapy meropenem-nonsusceptible bacteria meropenem-resistant bacteria pharmacokinetic/pharmacodynamics Monte Carlo simulation
Онлайн доступ:	https://www.frontiersin.org/article/10.3389/fmicb.2019.02777/full
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