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Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease

In order to test the hypothesis that fish-eye disease (FED) is due to a deficient activation of lecithin:cholesterol acyltransferase (LCAT) by its co-factor apolipoprotein (apo) A-I, we overexpressed the natural mutants T123I, N131D, N391S, and other engineered mutants in Cos-1 cells. Esterase activ...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Berlinda Vanloo, Frank Peelman, Kristof Deschuymere, Josee Taveirne, Annick Verhee, Catherine Gouyette, Christine Labeur, Joël Vandekerckhove, Jan Tavernier, Maryvonne Rosseneu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2000-05-01
Rangatū:Journal of Lipid Research
Ngā marau:
cholesterol
phospholipid
enzyme
lipase
HDL
LDL
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S0022227520323841
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