Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution

Abstract Systematic whole-protein screening and comprehensive profiling of antigen-specific CD4+ T cells are crucial for advancing vaccine design and cancer immunotherapies, yet remain technically challenging. Here, we present a high-throughput platform that utilizes large-scale class II single-chai...

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Autors principals:	Rongyu Zhang, Jingqi Qi, Michaela McKasson, Jongchan Choi, Vanessa Gutierrez, Conor Brennan, Sunga Hong, William Chour, Rachel H. Ng, Jingyi Xie, Dan Yuan, Andrew Webster, Simranjeet K. Sidhu, Abby Anderson, Daniel Chen, Rick Edmark, Kim M. Murray, Sarah Li, Connor McDonald, Lee Rowen, Shuo Wang, Yusuf Rasheed, Yapeng Su, Jamie R. Wagner, Jia Ming Chen, Karla Nawaly, Jie Fu, Alexandria Duven, Stephen J. Forman, Mihae Song, Saul J. Priceman, Christine E. Brown, Antoni Ribas, Deborah J. Wong, Kelly G. Paulson, Charles W. Drescher, Cristina Puig-Saus, Jason D. Goldman, Cornelia L. Trimble, James R. Heath
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-72396-7
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