Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety

Objective: Dextromethorphan (DXM) is a commonly used antitussive medication with positive effects in people with type 2 diabetes mellitus, since it increases glucose tolerance and protects pancreatic islets from cell death. However, its use as an antidiabetic medication is limited due to its central...

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Detalhes bibliográficos

Principais autores:	Okka Scholz, Elena Huß, Silke Otter, Diran Herebian, Anna Hamacher, Laura Mariana Levy, Stanimira Hristeva, Miguel Sanz, Haresh Ajani, Alfredo Rodriguez Puentes, Torsten Hoffmann, Jens Hogeback, Anke Unger, Susanne Terheyden, Michelle Reina do Fundo, Bedair Dewidar, Michael Roden, Eckhard Lammert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-09-01
coleção:	Molecular Metabolism
Assuntos:	Diabetes mellitus Pancreatic islets Drug discovery Dextromethorphan Pancreatic islet cell protection Blood–brain barrier
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877823001096
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