High-throughput analysis of the Trypanosoma cruzi minicirculome (mcDNA) unveils structural variation and functional diversity

Abstract Trypanosoma cruzi causes Chagas disease and has a unique extranuclear genome enclosed in a structure called the kinetoplast, which contains circular genomes known as maxi- and minicircles. While the structure and function of maxicircles are well-understood, many aspects of minicircles remai...

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Detalhes bibliográficos

Principais autores:	Andrés Gómez-Palacio, Lissa Cruz-Saavedra, Frederik Van den Broeck, Manon Geerts, Sebastián Pita, Gustavo A. Vallejo, Julio C. Carranza, Juan David Ramírez
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-03-01
coleção:	Scientific Reports
Assuntos:	Trypanosoma cruzi Maxicircles Minicircles kDNA Guide RNA Colombia
Acesso em linha:	https://doi.org/10.1038/s41598-024-56076-4
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