Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in Plasmodium falciparum parasites

ABSTRACT Reduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in kelch13 (k13) but also in other genes, like ubp1. K13 and its compartment neighbors (KICs), including UBP1, are involved in endocytos...

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Hlavní autoři:	Hannah M. Behrens, Sabine Schmidt, Isabelle G. Henshall, Patricia López-Barona, Domitille Peigney, Ricarda Sabitzki, Jürgen May, Oumou Maïga-Ascofaré, Tobias Spielmann
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2024-06-01
Edice:	mBio
Témata:	artemisinin malaria Plasmodium falciparum ART resistance Kelch13 fitness cost
On-line přístup:	https://journals.asm.org/doi/10.1128/mbio.01981-23
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