Targeting the PRMT1 axis in cancer: from epigenetic plasticity to contextual therapeutic interventions

Protein arginine methyltransferase 1 (PRMT1), the predominant Type I arginine methyltransferase, is reported to play the key role in regulating cancer epigenetics. Its activity directs gene expression, chromatin structure and transcriptional activation by mediating asymmetric dimethylation of histon...

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Autors principals:	Shahper Nazeer Khan, Aamir Ahmad, Mohd Haris Siddiqui
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-07-01
Col·lecció:	Frontiers in Oncology
Matèries:	arginine methylation epigenetic cross-talk PRMT1 axis PRMT1 inhibitors therapeutic target
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1841266/full
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