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A Sensitive LC–MS/MS Method for the Quantification of 3-Hydroxybenzo[<i>a</i>]pyrene in Urine-Exposure Assessment in Smokers and Users of Potentially Reduced-Risk Products

Benzo[<i>a</i>]pyrene (BaP), a human carcinogen, is formed during the incomplete combustion of organic matter such as tobacco. A suitable biomarker of exposure is the monohydroxylated metabolite 3-hydroxybenzo[<i>a</i>]pyrene (3-OH-BaP). We developed a sensitive LC–MS/MS (liquid chromatography coupl...

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Principais autores: Nadine Rögner, Heinz-Werner Hagedorn, Gerhard Scherer, Max Scherer, Nikola Pluym
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-10-01
Serier:Separations
Fag:
3-hydroxybenzo[<i>a</i>]pyrene
LC–MS/MS
urine
human biomonitoring
derivatization
potentially reduced-risk products
Online adgang:https://www.mdpi.com/2297-8739/8/10/171
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