Upregulation of EphA4 deteriorate brain damage by shifting microglia M1-polarization via NF-κB signaling after focal cerebral ischemia in rats

Ischemic stroke is the main reason of disability and mortality in many countries, and currently has limited treatments. The post-stroke inflammation characterized with microglia activation and polarization has been regarded as a promising therapeutic target for ischemic stroke. After ischemia, the a...

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Principais autores:	Hui-Xing Wei, Yun-Ni Guan, Ping-Ping Chen, Zhao-Zeng Rao, Jin-Shan Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-07-01
coleção:	Heliyon
Assuntos:	Ischemic stroke Post-stroke inflammation Neuronal EphA4 Microglia polarization NF-κB signaling
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405844023056372
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