Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline

Abstract Background Tigecycline is a tetracycline derivative that constitutes one of the last-resort antibiotics used clinically to treat infections caused by both multiple drug-resistant (MDR) Gram-negative and Gram-positive bacteria. Resistance to this drug is often caused by chromosome-encoding m...

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Detalhes bibliográficos

Principais autores:	Qipeng Cheng, Yanchu Cheung, Chenyu Liu, Qingjie Xiao, Bo Sun, Jiahai Zhou, Edward Wai Chi Chan, Rong Zhang, Sheng Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-12-01
Colecção:	BMC Biology
Assuntos:	Tet(X4) Variant Tigecycline FAD binding Secondary structure
Acesso em linha:	https://doi.org/10.1186/s12915-021-01199-7
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