Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity
Abstract Mutations in the Presenilin genes are the major genetic cause of Alzheimer's disease (AD). Presenilin (PS) is highly expressed in the hippocampus, which is particularly vulnerable in AD. Previous studies of PS function in the hippocampus, however, focused exclusively on excitatory neurons....
में बचाया:
| मुख्य लेखकों: | , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
BMC
2021-05-01
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| श्रृंखला: | Molecular Brain |
| विषय: | |
| ऑनलाइन पहुंच: | https://doi.org/10.1186/s13041-021-00796-5 |
| टैग: |
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