Ex vivo lung-organoid model for aberrant basaloid cell induction and activation

Abstract Background Pulmonary fibrosis (PF) is a severe lung disease characterized by the destruction of lung architecture resulting from chronic epithelial injury. The PF microenvironment induces PF-specific epithelial cells, such as aberrant basaloid cells (ABCs). However, limited experimental mod...

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Autors principals:	Bin Wu, Shigeyuki Shichino, Satoshi Ueha, Rina Matsukiyo, Yu Ishimura, Haru Ogiwara, Masaki Takasu, Shotaro Yamano, Yumi Umeda, Kouji Matsushima
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Inflammation and Regeneration
Matèries:	Three-dimensional lung organoid Lung epithelial injury Aberrant basaloid cells Idiopathic pulmonary fibrosis
Accés en línia:	https://doi.org/10.1186/s41232-025-00396-z
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