β-Adrenergic Receptor Desensitization/Down-Regulation in Heart Failure: A Friend or Foe?
Cardiac sympathetic activation, mediated by β-adrenergic receptors (β-ARs), normally increases cardiac contraction and relaxation. Accomplishing this task requires a physiological, concerted Ca2+ signaling, being able to increase Ca2+ release from sarcoplasmic reticulum (SR) in systole and speed up...
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| Автори: | , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Frontiers Media S.A.
2022-07-01
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| Серія: | Frontiers in Cardiovascular Medicine |
| Предмети: | |
| Онлайн доступ: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.925692/full |
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