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PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients

BackgroundHCV eradication with antiviral treatment reduces hepatic disease, but some patients remain at risk of progression to cirrhosis despite HCV clearance. We aimed to examine the association between peripheral blood mononuclear cells (PBMCs) gene expression before HCV therapy and a pronounced d...

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Principais autores: Ana Virseda-Berdices, Óscar Brochado-Kith, Juan Berenguer, Juan González-García, Leire Pérez-Latorre, Carmen Busca, Cristina Díez, Rafael Micán, Amanda Fernández-Rodríguez, María Ángeles Jiménez-Sousa, Salvador Resino
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-01-01
coleção:Frontiers in Pharmacology
Assuntos:
HIV/HCV coinfection
gene expression
RNA-seq
PBMCs
liver stiffness
HCV treatment
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2024.1436198/full
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