Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling

Abstract Background Almonertinib is a third-generation EGFR-TKI, and studies on its resistance mechanisms are lacking. Cancer-associated fibroblasts (CAFs) can influence resistance to targeted therapeutics, but their role and mechanism of action in relation to almonertinib resistance are unclear. Th...

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Główni autorzy:	Guohao Wei, Lingyao Fan, Xiaoyan Song, Wenzheng Zhou, Min Sun, Yan Sun, Yuhui Yao, Huihui Zhao, Fangfang Chen, Chuandong Zhu
Format:	Artigo
Język:	Inglês
Wydane:	Springer 2025-02-01
Seria:	Discover Oncology
Hasła przedmiotowe:	EGFR-TKI Almonertinib Cancer-associated fibroblast Glycolysis Hexokinases II
Dostęp online:	https://doi.org/10.1007/s12672-025-01974-w
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