Functional Expression of Recombinant <i>Candida auris</i> Proteins in <i>Saccharomyces cerevisiae</i> Enables Azole Susceptibility Evaluation and Drug Discovery

<i>Candida auris</i> infections are difficult to treat due to acquired drug resistance against one or multiple antifungal drug classes. The most prominent resistance mechanisms in <i>C. auris</i> are overexpression and point mutations in Erg11, and the overexpression of efflux pump genes <i>CDR1</i>...

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Autors principals:	Stephanie Toepfer, Michaela Lackner, Mikhail V. Keniya, Brian C. Monk
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-01-01
Col·lecció:	Journal of Fungi
Matèries:	<i>Candida auris</i> yeast heterologous expression platform azole resistance multidrug resistance emerging pathogens amino acid substitutions
Accés en línia:	https://www.mdpi.com/2309-608X/9/2/168
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