Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems

Background: The current research aims to improve the oral bioavailability of ibrutinib (IBR), a class II drug with low solubility, through the formulation of nanosponges (NSPs) that incorporate IBR, utilizing Hydroxypropyl β-cyclodextrin (HPβCD) and 1,1′-carbonyldiimidazole (CDI) as cross-linking ag...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Sunitha Sampathi, Nitiraj Kulkarni, D.V.R.N. Bhikshapathi, Jagadish V. Tawade, Nainaru Tarakaramu, Rzgar Farooq Rashid, Aziz Kubaev
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2025-01-01
Σειρά:	Current Research in Pharmacology and Drug Discovery
Θέματα:	Cross-linker 1,1′-carbonyldiimidazole Hydroxypropyl β-cyclodextrin Ibrutinib Sustained release QbD
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S259025712500001X
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!