Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs

The source of where definitive hematopoietic stem cells (dHSCs) develop in the mouse embyro has been much debated. Here, the authors identify that dHSCs arise from the intra-embyronic region by using murine embryonic explant transplantation but not from the yolk sac.

Bibliografski detalji

Glavni autori:	Miguel Ganuza, Ashley Chabot, Xing Tang, Wenjian Bi, Sivaraman Natarajan, Robert Carter, Charles Gawad, Guolian Kang, Yong Cheng, Shannon McKinney-Freeman
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2018-12-01
Serija:	Nature Communications
Online pristup:	https://doi.org/10.1038/s41467-018-07769-8
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