Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trialsResearch in context

Summary: Background: Lassa fever (LF) is a zoonotic haemorrhagic disease caused by Lassa virus (LASV), which is endemic in West African countries. The multimammate rat is the main animal reservoir and its geographic range is expected to expand due to influences like climate change and land usage, a...

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Principais autores:	Christopher L. Cooper, Gavin Morrow, Maoli Yuan, Thomas S. Postler, Maxwell L. Neal, Robert W. Cross, Courtney Woolsey, Krystle N. Agans, Viktoriya Borisevich, Ryan P. McNamara, Caroline Atyeo, Vicky Roy, Daritza Germosen, Fuxiang Hou, Shui L. Li, Lucia Reiserova, Yesle Choi, Aaron Wilson, Denise Wagner, Olivia Wallace-Selman, Alexei Carpov, Fuqiang Geng, Deborah J. Frederick, Joanne DeStefano, Anne M. Ercolini, Adrian S. Enriquez, Kathryn M. Hastie, Suzane Ramos da Silva, Eddy Sayeed, John W. Coleman, Andrew Kilianski, Galit Alter, Erica Ollmann Saphire, John D. Aitchison, Thomas W. Geisbert, Swati B. Gupta, Mark B. Feinberg, Christopher L. Parks
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-04-01
Series:	EBioMedicine
Assuntos:	Lassa virus Vesicular stomatitis virus vector Clinical vaccine candidate Neutralizing antibodies
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S235239642500091X
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