Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies

BackgroundHigh-grade serous ovarian cancer (HGSOC), the predominant subtype of epithelial ovarian cancer, is frequently diagnosed at an advanced stage due to its nonspecific early symptoms. Despite standard treatments, including cytoreductive surgery and platinum-based chemotherapy, significant impr...

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Главные авторы:	Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2025-01-01
Серии:	Frontiers in Immunology
Предметы:	high-grade serous ovarian cancer (HGSOC) prognostic model immunotherapy molecular mechanisms tumor microenvironment multi-omics
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500153/full
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