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Optimizing the design of a pharmacokinetic trial to evaluate the dosing scheme of a novel tuberculosis drug in children living with or without HIV

Abstract Pharmacokinetic (PK) studies in children are usually small and have ethical constraints due to the medical complexities of drawing blood in this special population. Often, population PK models for the drug(s) of interest are available in adults, and these models can be extended to incorpora...

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Principais autores: Grace Montepiedra, Elin M. Svensson, Weng Kee Wong, Andrew C. Hooker
Format: Artigo
Jezik:Inglês
Izdano: Wiley 2024-02-01
Serija:CPT: Pharmacometrics & Systems Pharmacology
Online dostop:https://doi.org/10.1002/psp4.13077
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