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Involvement of Transporters in Intestinal Drug–Drug Interactions of Oral Targeted Anticancer Drugs Assessed by Changes in Drug Absorption Time

(1) Background: Oral targeted anticancer drugs are victims of presystemic pharmacokinetic drug–drug interactions (DDI). Identification of the nature of these DDIs, i.e., enzyme-based or/and transporter-based, is challenging, since most of these drugs are substrates of intestinal and/or hepatic cytoc...

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Principais autores: David Malnoë, Olivier Fardel, Pascal Le Corre
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-11-01
סדרה:Pharmaceutics
נושאים:
intestinal absorption rate
t<sub>max</sub>
mean absorption time
intestinal transporters
mathematical solving
presystemic drug–drug interactions
גישה מקוונת:https://www.mdpi.com/1999-4923/14/11/2493
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