Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Abstract CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs. CYP3A4 is involved in the metabolism of 50% of drugs on the market, whereas CYP2D6 is involved in the metabolism of 25% of them. CYP2...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Wiley
2022-04-01
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| Collection: | Pharmacology Research & Perspectives |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1002/prp2.939 |
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