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Mammalian synthetic gene circuits for biopharmaceutical development & manufacture

Abstract This paper reviews the design and application of mammalian synthetic gene circuits for biopharmaceutical manufacturing. It discusses key design principles and outlines transcription factors, DNA-binding proteins, and RNA as input and regulatory modules, while also presenting computational m...

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Principais autores: Sheryl Li Yan Lim, Sofia Gialamoidou, Rajinder Kaur, Ioscani Jimenez del Val
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-12-01
Series:npj Systems Biology and Applications
Acceso en liña:https://doi.org/10.1038/s41540-025-00621-y
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