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Endothelial Unc5B controls blood-brain barrier integrity

The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.

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Auteurs principaux: Kevin Boyé, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L. Ackerman, Anne Eichmann
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2022-03-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-022-28785-9
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