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Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N

Acquired anaplastic lymphoma kinase (ALK) mutation is the major resistant mechanism to ALK tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) patients. At present, treatment options after acquiring secondary ALK mutations are still limited. Here, we report on a patient with meta...

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Váldodahkkit: Na Li, Huihui Li, Ding Wang, Xiaoling Xu
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2023-12-01
Ráidu:Frontiers in Pharmacology
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Liŋkkat:https://www.frontiersin.org/articles/10.3389/fphar.2023.1197163/full
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