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METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy

Summary: The role of neurotransmitters in suppressing anti-tumor immunity has garnered increasing attention. While glutamate has been extensively studied in neurological diseases, its potential role in regulating anti-tumor immunity, particularly in the context of neoadjuvant immunochemotherapy, rem...

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Príomhchruthaitheoirí: Chunyu Feng, Su-Ran Li, Xiaoshuai Xu, Zihan Dang, Zihan Jiang, Erhui Jiang, Zhengjun Shang
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2026-02-01
Sraith:Cell Reports
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Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211124726000112
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