Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo

IntroductionSystemic sclerosis (SSc) is an autoimmune disease characterized by antinuclear antibody production, which has been linked to an excess of apoptotic cells, normally eliminated by macrophages through efferocytosis. Additionally, circulating levels of CXCL4, a novel SSc biomarker, correlate...

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Hlavní autoři:	Erwan Le Tallec, Nessrine Bellamri, Marie Lelong, Claudie Morzadec, Quentin Frenger, Alice Ballerie, Claire Cazalets, Alain Lescoat, Frédéric Gros, Valérie Lecureur
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-10-01
Edice:	Frontiers in Immunology
Témata:	CXCL4 efferocytosis fibrosis macrophage phagocytosis systemic sclerosis
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1468821/full
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