Combating small extracellular vesicle–mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides

Abstract Tumor cell-derived small extracellular vesicles (TDEs) play a critical role in immune evasion, including the establishment of an immunosuppressive tumor microenvironment (TME), and form a substantial barrier to effective cancer immunotherapy. Here, we introduce the ExoPERM (pH-enabled ruptu...

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Detalhes bibliográficos

Principais autores:	Chan Ho Kim, Hyewon Ko, Jae Ah Lee, So Hee Kim, Minsung Park, Chang Hyun Lee, Sol Shin, Jung Min Shin, Soyoung Son, Jeongjin Lee, Heegun Kang, Sohyun Cho, Joonsuk Chang, Jiyeon Kim, Won Ho Jang, Min Jun Kim, Joshua A. Jackman, Jae Hyung Park
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-05-01
Colecção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-026-02736-y
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