Tocilizumab attenuates choroidal neovascularization by regulating macrophage polarization through the IL-6R/STAT3/VEGF pathway

Globally, age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment. Up to 80% of severe vision loss is caused by AMD, which is characterized by the development of choroidal neovascularization (CNV). Uncertainty exists regarding the precise pathophysiological mech...

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Bibliografische Detailangaben

Hauptverfasser:	Yuanyuan Tu, Yang Guo, Haotian Sun, Yuting Zhang, Qiaoyun Wang, Yiqian Xu, Laiqing Xie, Manhui Zhu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-03-01
Schriftenreihe:	Heliyon
Schlagworte:	Choroidal neovascularization TCZ IL-6 Macrophage polarization
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405844024039240
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