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Complement in Thrombotic Microangiopathies: Unraveling Ariadne's Thread Into the Labyrinth of Complement Therapeutics

Thrombotic microangiopathies (TMAs) are a heterogeneous group of syndromes presenting with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. We currently recognize two major entities with distinct pathophysiology: thrombotic thrombocytopenic purpura (T...

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Principais autores: Eleni Gavriilaki, Achilles Anagnostopoulos, Dimitrios C. Mastellos
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-02-01
Serier:Frontiers in Immunology
Fag:
thrombotic microangiopathy
complement inhibitors
hemolytic uremic syndrome
HELLP syndrome
transplant-associated thrombotic microangiopathy
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.00337/full
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