Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility

Abstract A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura borylation and Suzuki coupling methodology. Biaryl bridges formed by side chains of the two aromatic amino acid residues are of the meta–meta, meta–p...

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Bibliografiske detaljer

Principais autores:	Maria Różanowska, Gabriela Szczupaj, Michał Nowakowski, Priyadharshni Rajagopal, Piotr F. J. Lipiński, Joanna Matalińska, Aleksandra Misicka, Marek Lisowski, Łukasz Jaremko, Mariusz Jaremko
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2024-03-01
Serier:	Amino Acids
Fag:	Cyclization Biaryl bridges in peptides Miyaura–Suzuki reaction NMR CD Molecular docking
Online adgang:	https://doi.org/10.1007/s00726-023-03371-5
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