Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers

BackgroundThe World Health Organization highlighted the potential protective role of exercise against cognitive decline, all-cause dementia, Alzheimer’s disease (AD), and vascular dementia in healthy individuals. We have previously shown that exercise is particularly beneficial for older, cognitivel...

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Huvudupphov:	Stephen M. Rao, Alexandria L. Chorba, M. J. Helppi, Alina Tuladhar, Amanda L. Penko, Sarah Holley, Brandon Nehls, Sabrina Paulino, Matthew C. Streicher, Audrey Zhu, Kellie Bruening, Sally Durgerian, Katherine Koenig, Mark Lowe, Wanyong Shin, Stephen E. Jones, Rachel Galioto, Jagan A. Pillai, Lynn M. Bekris, James B. Leverenz, Anson B. Rosenfeldt, Tamanna Singh, Gerald J. Beck, J. Carson Smith, Jay Alberts
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2025-05-01
Serie:	Frontiers in Aging Neuroscience
Ämnen:	Alzheimer’s disease exercise neuroprotection APOE ε4 randomized clinical trial
Länkar:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1584115/full
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