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PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) plays a critical role in craniofacial development. Phosphatidylinositol 3-kinase (PI3K)/Akt is the primary effector of PDGFRα signaling during mouse skeletal development. We previously demonstrated that Akt phosphorylates t...

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Principais autores: Thomas E Forman, Marcin P Sajek, Eric D Larson, Neelanjan Mukherjee, Katherine A Fantauzzo
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
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Acceso en liña:https://elifesciences.org/articles/98531
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