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Continuum of Core 1 biomarkers in preclinical Alzheimer’s disease

Abstract Background Biological Staging for Alzheimer’s disease (AD) in clinically unimpaired (CU) individuals is critical for early detection efforts. In this study, we evaluated whether Core 1 biomarkers (plasma p-tau217 and amyloid-PET) within Biological Stage A, the earliest biological stage of A...

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Main Authors: Leonardino A. Digma, Christina B. Young, Joseph R. Winer, Karly A. Cody, Kyan Younes, Jintao Sheng, Philip S. Insel, Robert A. Rissman, Reisa Sperling, Elizabeth C. Mormino
Format: Artigo
Language:Inglês
Published: BMC 2026-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Biological staging
preclinical Alzheimer’s disease
p-tau217
tau-PET
Online Access:https://doi.org/10.1186/s13195-026-02044-1
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