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Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in colorectal cancer

Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with its heterogeneous molecular profiles complicating prognosis prediction. Multi-omics profiling of clinical CRC specimens is particularly valuable for uncovering prognostic variables; however, such int...

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Main Authors: Tianwei Chen, Yebin Yang, Jing Shi, Fanhe Dong, Lesi Xie, Yuqiang Shan, Xiang Wang
Format: Artigo
Language:Inglês
Published: Springer 2025-12-01
Series:Molecular Biomedicine
Subjects:
Colorectal cancer
Multi-omics factor analysis
Myofibroblasts
Extracellular matrix
TNS1
FERMT2
Online Access:https://doi.org/10.1186/s43556-025-00386-0
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