Subtle changes in Purkinje cell firing in Purkinje cell-specific Dyt1 ΔGAG knock-in mice

DYT1 dystonia is an inherited early-onset generalized dystonia characterized by sustained muscle contractions causing abnormal, repetitive movements or postures. Most DYT1 patients have a heterozygous trinucleotide GAG deletion (ΔGAG) in DYT1/TOR1A, coding for torsinA. Dyt1 heterozygous ΔGAG knock-i...

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Autors principals:	Hong Xing, Pallavi Girdhar, Yuning Liu, Fumiaki Yokoi, David E. Vaillancourt, Yuqing Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-01-01
Col·lecció:	Dystonia
Matèries:	Purkinje cells dystonia torsinA DYT1 electrophysiology
Accés en línia:	https://www.frontierspartnerships.org/articles/10.3389/dyst.2025.14148/full
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