Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus

Objective To evaluate the effects of targeting Ikaros and Aiolos by cereblon modulator iberdomide on the activation and differentiation of B-cells from patients with systemic lupus erythematosus (SLE).Methods CD19+ B-cells isolated from the peripheral blood of patients with SLE (n=41) were cultured...

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Bibliographic Details

Main Authors:	Costantino Pitzalis, Michele Bombardieri, Patrick Gordon, Daniele Mauro, Felice Rivellese, Debasish Pyne, Myles J Lewis, Katriona Goldmann, Sotiria Manou-Stathopoulou, Ravindra Rajakariar, Peter Schafer
Format:	Artigo
Language:	Inglês
Published:	BMJ Publishing Group 2021-05-01
Series:	Lupus Science and Medicine
Online Access:	https://lupus.bmj.com/content/8/1/e000445.full
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