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Landscape of T-cell exhaustion heterogeneity and HBV integration in virus-related HCC revealed by whole-exome, transcriptome, and single-cell sequencing

Background & Aims: To enhance our understanding of the tumor immune microenvironment (TIME) in hepatocellular carcinoma (HCC), we investigated the heterogeneity of T-cell exhaustion and its association with HBV integrations and direct oncogenic potential in HCC. Methods: We conducted a multi-omi...

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Principais autores: Soon Kyu Lee, Jinyeong Lim, Joo Yeon Jhun, Jeonghyeon Moon, Hye Seon Kim, Jong Young Choi, Ho Joong Choi, Young Kyoung You, Ji Won Han, Pil Soo Sung, Kwon Yong Tak, Seung Kew Yoon, Woong-Yang Park, Mi-La Cho, Jeong Won Jang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-11-01
coleção:JHEP Reports
Assuntos:
Hepatocellular carcinoma
T cell
HBV integration
Single-cell RNA sequencing
Whole-exome sequencing
Whole-transcriptome sequencing
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S258955592500196X
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