Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain

Abstract Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in Alzheimer’s disease (AD). However, the precise relationship between tau seeding measured by SAA and the levels of...

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Detalhes bibliográficos

Principais autores:	Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-11-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Alzheimer’s disease Tau seeding Seed amplification assay (SAA) Real-time quaking induced conversion assay (RT-QuIC)
Acesso em linha:	https://doi.org/10.1186/s40478-023-01676-w
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