Novel indole-based sulfonate and sulfamate derivatives as potent and selective urease inhibitors targeting Helicobacter pylori: a promising therapeutic strategy

Abstract Helicobacter pylori (H. pylori) infection is strongly associated with peptic ulcer and gastric cancer, compounded by the growing prevalence of antibiotic resistance. Current antibiotic eradication therapies often lead to gut dysbiosis and treatment failure, highlighting the urgent need for...

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Hauptverfasser:	Ghalia Khoder, Esra M. Mustafa, Sumera Zaib, Anil Ravi, Afnan I. Shahin, Seyed-Omar Zaraei, Nehal Rana, Hanan S. Anbar, Hafiz Saqib Ali, Shamsul Qumar, Merylin Sebastian, Ragheb Alsheikh Zein, Mohammed I. El-Gamal
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	Gut Pathogens
Schlagworte:	Helicobacter pylori Indole-Based Sulfonate and Sulfamate Derivatives Urease Inhibitors, Antibiotic resistance
Online-Zugang:	https://doi.org/10.1186/s13099-026-00814-8
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